Fig 2.

Organization of the CCR5 promoter and methylation analysis of several cell types. Each circle represents a single CpG residue. The percentage of clones methylated at a specific residue is indicated by the black colour. The distance between each circle represents the relative distance between CpG residues on the genomic sequence. Horizontal arrows indicate the relative position of primers used to amplify bisulphite modified DNA. The CREB-1 binding site most likely involved in CCR5 transactivation is indicated with a vertical arrow [26].