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(A) Acetylation of AR occurs at lysine residues 630, 632, and 633 and is mediated by interactions with coregulators with intrinsic histone acetyltransferase (HAT) activity, such as coactivators p300, P/CAF and TIP60 (Tat-interactive protein). (B) Acetylation mimicking mutants (K630Q/K630T) exhibited increased cell growth in prostate cancer cell lines.
