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(A) Sumoylation of ERα occurs at lysine residues 266 and 268 (K266 and K268). (B) Unstimulated estrogen receptor is ubiquitinated and degraded by carboxyl terminus of Hsp70-interacting protein (CHIP), an ubiquitin E3 ligase. Fulvestrant (ICI 182,780), a pure anti-estrogen, utilizes the ubiquitination mechanism to induce proteasome-dependent degradation of ERα.
