Table 4.
Results from the Poisson test comparing the observed and expected mutation rates by base pair in all HPE genes.
| Gene | Group | Ratioa | 95%CIb | P-valuec |
|---|---|---|---|---|
| SHH | NIH | 3237.8 | (1552.6, 5954.6) | 2.17×10−32 |
| French | 4589.6 | (2568.7, 7570) | 3.95×10−50 | |
| Dutch | 2134.7 | (440.2, 6238.7) | 4.62×10−10 | |
| Aggregate | 3607.3 | (2397, 5213.6) | 2.71×10−89 | |
| ZIC2 | NIH | 4051.7 | (1852.7, 7691.5) | 3.62×10−30 |
| French | 3403.4 | (1469.3, 6706.2) | 2.31×10−26 | |
| Dutch | 7914.9 | (3417, 15596.2) | 2.70×10−29 | |
| Aggregate | 4478.2 | (2898, 6610.7) | 3.01×10−82 | |
| SIX3 | NIH | 551.1 | (14, 3070.8) | 1.81×10−3 |
| French | 1041.7 | (126.1, 3762.9) | 1.84×10−6 | |
| Dutch | d | d | d | |
| Aggregate | 657.9 | (135.7, 1922.7) | 1.57×10−8 | |
| TGIF | NIH | 1341.5 | (579.2, 2643.3) | 3.95×10−23 |
| French | 1109.2 | (446, 2285.5) | 7.86×10−20 | |
| Dutch | 2948.2 | (1272.8, 5809.2) | 7.27×10−26 | |
| Aggregate | 1534.6 | (972.8, 2302.7) | 4.20×10−65 |
a
Quotient between the observed mutation rate per base pair and a baseline mutation rate per base pair estimated as 1 in 85 million [Hesman-Saey, 2011].
b
Confidence Interval.
c
Two-tailed P-value comparing the observed and expected mutation rates.
d
Statistical test could not be performed as zero events occurred.