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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Mol Genet Metab. 2012 Jan 12;105(4):658–664. doi: 10.1016/j.ymgme.2012.01.005

Table 5.

Number of HPE patients M to be screened as a function of N, the number of observed patients with one “double hit” in genes G1 and G2 when a type I error probability α=0.05 is used. Mutation frequencies per gene were calculated using the aggregate data in Table 1.

N Pair of genes
SHH/ZIC2 SHH/SIX3 SHH/TGIF ZIC2/SIX3 ZIC2/TGIF SIX3/TGIF
1 2211 2042 16243 2460 19567 18078
2 2846 2629 20911 3167 25190 23273
3 3442 3180 25293 3830 30469 28149
4 4013 3708 29492 4466 35528 32823
5 4567 4219 33563 5083 40432 37354
6 5108 4719 37537 5684 45218 41776
7 5638 5209 41433 6274 49912 46113
8 6159 5690 45267 6855 54530 50379
9 6674 6166 49048 7427 59085 54587
10 7182 6635 52784 7993 63586 58746
11 7685 7100 56481 8553 68039 62861
12 8183 7560 60144 9107 72452 66938
13 8677 8017 63778 9657 76829 70981
14 9168 8470 67384 10203 81173 74995
15 9655 8920 70966 10746 85488 78981