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Hypothetical roles of Ang2 in metastasis and the pre-metastatic niche based on recent studies and the effects of Ang2 blockade on dissemination and development of metastasis. Ang2 = angiopoeitin 2; TEM = Tie2-expressing macrophage; Tie2 = tyrosine kinase with immunoglobulin and epidermal growth factor homology domains; VEGF = vascular endothelial growth factor.
