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Flow diagram of the Breast International Group (BIG) 1-98 trial participants included in the study. Collection of tumor tissue blocks, DNA extraction, CYP2D6 genotyping, and patient cohorts for analysis are shown. BCFI = breast cancer-free interval; CYP2D6 = Cytochrome P450 2D6; ER = estrogen receptor; FFPE = formalin-fixed paraffin-embedded.
