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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Arch Toxicol. 2011 Nov 22;86(4):633–642. doi: 10.1007/s00204-011-0778-y

Fig. 5. Resveratrol increases NRF-1 expression through genomic ER activity in HUVECs and ablates inhibition of basal NRF-1 expression by DEPEsL75 and S80.

Fig. 5

(A) HUVECs were treated with EtOH or increasing concentrations of resveratrol. (B) Where indicated, HUVECs were pretreated with 100 nM ICI 182,780 for 6 h; 50 nM Wortmannin (Wort), 50 mM PD98059 (PD), or 50 nM pertussis toxin (PTX); or 10 μg/ml DEPE L59, L75, S50, or S80 for 1 h followed by the addition of 10 nM resveratrol for 4 h. Total mRNA was isolated following treatment and QRT-PCR was performed as described in Material and Methods. Values are the average of 3 separate experiments ± SEM. * p < 0.05 versus EtOH; ** p < 0.05 versus resveratrol.