Table 5.

 Unadjusted and adjusted hazard ratios at predefined levels of interarm differences in blood pressure in participants without pre-existing vascular disease (n=183)

Interarm difference	Unadjusted hazard ratio	Adjusted hazard ratio model 1*	P value†	Adjusted hazard ratio model 2‡	P value§
Combined cardiovascular and cerebrovascular events
Systolic blood pressure cut-off:
10 mm Hg	3.5 (2.1 to 6.1)	3.1 (1.8 to 5.5)	<0.001	3.0 (1.7 to 5.3)	<0.001
15 mm Hg	3.3 (1.7 to 6.3)	2.9 (1.5 to 5.5)	0.005	3.2 (1.6 to 6.4)	0.002
Diastolic blood pressure cut-off:
10 mm Hg	2.1 (0.9 to 4.9)	2.1 (0.9 to 4.8)	0.129	3.2 (1.2 to 7.9)	0.032
Cardiovascular deaths
Systolic blood pressure cut-off:
10 mm Hg	5.5 (2.2 to 13.8)	4.2 (1.7 to 10.8)	0.002	3.7 (1.4 to 9.9)	0.007
15 mm Hg	3.1 (1.1 to 8.5)	2.2 (0.8 to 6.0)	0.170	2.8 (1.0 to 8.3)	0.079
Diastolic blood pressure cut-off:
10 mm Hg	1.6 (0.4 to 6.8)	1.8 (0.4 to 8.0)	0.452	2.1 (0.4 to 11.0)	0.418
All deaths
Systolic blood pressure cut-off:
10 mm Hg	3.4 (1.9 to 6.1)	2.8 (1.5 to 5.0)	0.001	2.6 (1.4 to 4.8)	0.002
15 mm Hg	3.0 (1.5 to 6.0)	2.3 (1.2 to 4.6)	0.026	2.7 (1.3 to 5.4)	0.012
Diastolic blood pressure cut-off:
10 mm Hg	0.7 (0.2 to 2.7)	0.8 (0.2 to 3.1)	0.679	1.1 (0.3 to 4.8)	0.891
Events or deaths
Systolic blood pressure cut-off:
10 mm Hg	3.2 (2.0 to 5.0)	2.8 (1.8 to 4.5)	<0.001	2.7 (1.7 to 4.4)	<0.001
15 mm Hg	2.8 (1.7 to 5.3)	2.6 (1.5 to 4.6)	0.003	2.8 (1.6 to 5.1)	0.002
Diastolic blood pressure cut-off:
10 mm Hg	1.5 (0.6 to 3.4)	1.5 (0.6 to 3.4)	0.401	2.4 (1.0 to 5.9)	0.080

*Adjusted for Framingham 10 year cardiovascular risk score.

†P value for likelihood ratio testing from omission of interarm differences from multivariable model 1.

‡Adjusted as for model 1 plus mean blood pressure and presence of diabetes.

§P value for likelihood ratio testing from omission of interarm differences from multivariable model 2.