Table II.

Final total MPA pharmacokinetic parameter estimates in HCT recipients receiving IV MMF

Pharmacokinetic Parameter	Explanation	Estimate [RSE%a]	Bootstrap Analysis
			Median	95% CI [2.5th–97.5th percentile]
km (1/h)	First-order metabolizing rate constant of MMF to MPA	1.69 [14.4]	1.70	[1.46 – 2.60]
CL (L/h)	MPA clearance	36.9 [5.4]	36.4	[34.1 – 39.5]
Vc (L)	Volume of central compartment	11.9 [46.0]	11.3	[4.79 – 22.8]
Q (L/h)	Intercompartmental clearanceb	15.3 [12.9]	15.2	[12.4 – 18.7]
Vp (L)	Volume of peripheral compartment	182 [16.9]	200	[122– 300]
Inter-individual variability
η km (CV%)		17.0 [219.7]	24.9	[4.02 – 54.0]
η CL (CV%)		34.5 [25.0]	34.1	[28.5 – 39.5]
η Vc (CV%)		71.7 [114.2]	70.5	[40.2 – 131.1]
η Q (CV%)		80.4 [33.5]	79.9	[64.2 – 97.3]
η Vp (CV%)		127.3 [34.1]	127.5	[88.0 – 165.0]
Proportional error (CV%)		44.5 [9.2]	44.5	[36.9 – 49.0]
Additive error (mg/L)		0.10 [23.1]	0.09	[0.032 – 0.17]

^aRSE = relative standard error; CV = coefficient of variation;

^bbetween central and peripheral compartment;

^cmedian half-life estimate was 11.9 hr