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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Int J Radiat Oncol Biol Phys. 2012 Apr 1;82(5):1559–1566. doi: 10.1016/j.ijrobp.2010.12.032

Fig. 1.

Fig. 1

Effect of a single dose of whole brain irradiation on mRNA expression of MMPs and TIMPs in rat brain. Compared with sham-irradiated controls, a single dose of whole brain irradiation up-regulated mRNA expression of MMP-2 (A), MMP-9 (B), and TIMP-1 (C) in hippocampus and cortex, while the mRNA expression of TIMP-2 (D) was not affected by irradiation. Data shown are mean ± SEM for each group (n=4). *Statistically significant from control (p<0.05).