Table 1.

Thermodynamic and kinetic constants

Compound	Kaw(M−1)	CMC(M)	Klw apparent(M−1)	ΔH0(kJ/mol)	K1(M)	rb(1)	V1(%)	K2(M)	rb(2)	$\Delta {\text{G}}_{lw}^0/\Delta {\mathit{G}}_{tl\left(1\right)}^0$‖‖
C10-TAC	2.16 × 103	5.32 × 10−2	4.17 × 101§	n.m	2.68 × 10−3‖	1.12 × 10−1	372‖	n.d.	n.d.	3.2
C12-TAC	1.54 × 104	7.15 × 10−3	3.50 × 102§§	−9.74§§	1.59 × 10−4‖	1.39 × 10−1	344‖	n.d.	n.d.	4.1
C14-TAC	2.11 × 105	7.00 × 10−4	3.70 × 103§§	−8.51§§	3.02 × 10−5‖	1.12 × 10−1	247‖	n.d.	n.d.	4.9
C16-TAC	1.50 × 106	9.42 × 10−5	1.70 × 104§§	−4.81§§	4.40 × 10−6‖	7.48 × 10−2	153∗∗	n.d.	n.d.	5.7
C18-TAC	1.35 × 107	1.40 × 10−5	1.50 × 105§§	−0.76§§	—	—	—	—	—	6.6
C6-gluc	3.97 × 102	2.50 × 10−1‡	7.20 × 100§	n.m.	2.17× 10−2	1.32 × 10−1	125	3.64 × 10−2	2.22 × 10−1	2.3
C7-gluc	1.85 × 103	7.90 × 10−2	3.00 × 101§	n.m.	2.16 × 10−3	6.48 × 10−2	309	8.14 × 10−3	2.44 × 10−1	2.8
C8-gluc	1.02 × 104	2.30 × 10−2∗	1.20 × 102†	6.70†	1.75 × 10−4	2.10 × 10−2	110†	3.54× 10−3	4.25 × 10−1	3.2
C9-gluc	1.68 × 104	6.50 × 10−3	5.20 × 102¶¶	5.40¶¶	n.d.	n.d.	100	7.92 × 10−4	4.12 × 10−1	3.7
C10-gluc	9.76 × 104	2.20 × 10−3	1.60 × 103∗	4.90∗	n.d.	n.d.	100	3.26 × 10−4	5.22 × 10−1	4.2
C12-gluc	1.48 × 106	1.12 × 10−4	2.26 × 104§	−0.70‡‡	n.d.	n.d.	n.d.	n.d.	n.d.	5.1
C7-Tgluc	n.m.	2.90 × 10−2‡	6.00 × 101¶	n.m.	n.d.	n.d.	100	6.35 × 10−3	3.81 × 10−1	n.d.
C8-Tgluc	2.11 × 104	9.00 × 10−3‡	2.40 × 102†	−0.34†	n.d.	n.d.	100	1.46 × 10−3	3.50 × 10−1	n.d.
C9-Tgluc	4.41 × 104	2.20 × 10−3	1.04 × 103§	n.m.	n.d.	n.d.	113	2.20 × 10−4	2.50 × 10−1	n.d.
Anameg-7	7.87 × 103	1.95 × 10−2‡	100††	0.80††	3.59 × 10−4	3.59 × 10−2	260	1.60 × 10−3	1.60 × 10−1	2.7
Cyglu-3	n.m.	2.80 × 10−2‡	n.m.	n.m.	n.d.	n.d.	114	8.40 × 10−3	n.d.	n.d.
C6-malt	6.84 × 102	2.10 × 10−1‡	n.m.	n.m.	n.d.	n.d.	100	3.30 × 10−2	4.82 × 10−2	0.9
C8-malt	7.55 × 103	2.34 × 10−2	2.50 × 101∗	10.00∗	n.d.	n.d.	106	2.89 × 10−3	7.32 × 10−2	1.4
C9-malt	4.39 × 104	6.00 × 10−3‡	1.00 × 102∗	n.m.	n.d.	n.d.	100	2.86 × 10−4	2.86 × 10−2	1.7
C10-malt	1.55 × 105	2.02 × 10−3	2.00 × 102∗	14.00∗	n.d.	n.d.	100	1.60 × 10−4	3.20 × 10−2	1.9
C11-malt	n.m.	5.90 × 10−4‡	7.68 × 102‡‡	4.77‡‡	n.d.	n.d.	100	3.24 × 10−5	2.49 × 10−2	2.2
C12-malt	9.76 × 105	1.70 × 10−4	5.00 × 103∗	4.00∗	n.d.	n.d.	100	2.53 × 10−5	1.26 × 10−1	2.5
C13-malt	4.08 × 106	4.10 × 10−5	1.40 × 104‡‡	0.27‡‡	5.04 × 10−7	7.06 × 10−3	154	1.75 × 10−6	2.45× 10−2	2.7
C14-malt	1.27 × 107	1.30 × 10−5‡	4.60 × 104‖‖	n.m.	n.d.	n.d.	100	n.d.	n.d.	3.0
Cymal -1	n.m.	3.60 × 10−1‡	n.m.	n.m.	n.d.	n.d.	100	8.61 × 10−2	n.d.	n.d.
Cymal -2	n.m.	1.04 × 10−1‡	n.m.	n.m.	n.d.	n.d.	100	3.13 × 10−2	n.d.	n.d.
Cymal -3	n.m.	2.90 × 10−2‡	2.90 × 101¶	n.m.	n.d.	n.d.	100	4.44 × 10−3	1.29 × 10−1	n.d.
Cymal -4	n.m.	7.30 × 10−3‡	1.04 × 102¶	n.m.	n.d.	n.d.	100	1.10 × 10−3	1.14 × 10−1	n.d.
Cymal -5	n.m.	2.20 × 10−3‡	3.50 × 102††	1.05††	n.d.	n.d.	100	2.85 × 10−4	9.98 × 10−2	n.d.
Cymal -6	n.m.	5.60 × 10−4‡	1.50 × 103††	−0.46††	n.d.	n.d.	100	9.33 × 10−5	1.40 × 10−1	n.d.
Cymal -7	n.m.	1.90 × 10−4‡	4.50 × 103††	−0.31††	n.d.	n.d.	100	2.75 × 10−5	1.24 × 10−1	n.d.
FC8-malt	n.m.	1.02 × 10−3‡	4.00 × 102††	2.01††	n.d.	n.d.	100	3.54 × 10−4	1.42× 10−1	n.d.
Octanoylsucrose	n.m.	1.12 × 10−4	n.m.	n.m.	n.d.	n.d.	100	7.79 × 10−4	n.d.	n.d.
Sucrose monol.	1.10 × 106	2.14 × 10−4	n.m.	n.m.	n.d.	n.d.	100	2.63 × 10−5	n.d.	n.d.

n.m., not measured; n.d., not determined.

^∗Data taken from Heerklotz (38).

^†Data taken from Wenk and Seelig (39).

^‡Anatrace catalog.

^§Determined from surface activity measurements.

^¶Obtained from linear regression of $\Delta {\text{G}}_{\text{lw}}^0$ as a function of alkyl chain length, m.

^‖Evaluated from simple Michaelis-Menten equation.

^∗∗Maximum P-gp activity taken directly from measurement data.

^††Measured for LUVs (100 nm) at 37°C.

^‡‡Measured for LUVs (100 nm) at 25°C.

^§§Measured for SUVs (30 nm) at 37°C.

^¶¶Measured for SUVs (30 nm) at 28°C.

^‖‖Calculated from incremental values, except for Anameg-7.