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. Author manuscript; available in PMC: 2012 Mar 21.
Published in final edited form as: Anticancer Agents Med Chem. 2011 Jan;11(1):78–88. doi: 10.2174/187152011794941262

Table 2.

Phenotypic changes that occur upon overexpression or inhibition of PTPL1 expression : organization by tissues and cell lines.

Tissue Cell lines Phenotypic Observations PTPL1 effect
Hematopoietic cells Jurkat cells PTPL1 overexpression inhibits Fas apoptosis [8] ↓apoptosis
U937 myelomono-cytic leukemia cell SLV inhibitory peptide restores Fas apoptosis [63] ↓apoptosis
Colon DLD-1 SLV inhibitory peptide restores Fas apoptosis [54] ↓apoptosis
SW480 PTPL1 overexpression increases Fas apoptosis [61] ↑apoptosis
Inhibition of PTPL1 expression increases apoptosis induced by Oxaliplatin [64] ↓apoptosis
HCT-116 Inhibition of PTPL1 expression increases Fas apoptosis [65] ↓apoptosis
Inhibition of PTPL1 expression prevents RIL-induced Src inactivation [36] ↓ Src activation
Primary cultured cancer cells SLV inhibitory peptide restores Fas apoptosis [62] ↓Apoptosis
Stomach TMK1 PTPL1 overexpression decreases Fas apoptosis [57] ↓apoptosis
Pancreas Capan-1 pancreatic cancer cells PTPL1 overexpression decreases Fas apoptosis [58] ↓apoptosis
Panc89 pancreatic cancer cells Vanadate induces Fas sensitivity.
SLV inhibitory peptide restores Fas apoptosis [58]
↓apoptosis
INS-1 β-cells pancreatic β-cells PTPL1 overexpression inhibits INS-1 cell growth and antagonizes Wnt3a proliferative action[86] ↓ cell growth
Melanocytes FEMX
OM431
LU1205
Expression of PTPL1 reduces cell surface Fas level.
Inhibition of PTPL1 expression or expression of dominant-negative up-regulate surface Fas levels [59][66]
↓apoptosis
Breast MCF7 Inhibition of PTPL1 expression fails to restore Fas apoptosis and inhibits antioestrogen-induced apoptosis [73]
PTPL1 overexpression dephosphoryles IRS-1 and inhibits IGF-1 survival signaling [74]
Inhibition of PTPL1 expression induces xenograft growth, cell growth on Matrigel, cell invasiveness and Src activation [85]
↑apoptosis
↓ cell growth
↓ cell invasiveness
T47D Inhibition of PTPL1 expression induces cell growth on Matrigel, cell invasiveness and Src activation [85] ↓ cell growth
Brain D566
Glioblastoma
Inhibition of PTPL1 expression increases Fas apoptosis [60] ↓apoptosis
Ovary SKOV3 Inhibition of PTPL1 expression promotes invasiveness and Her2 signaling [76] ↓ cell invasiveness
Lung TIG3 embryonic fibroblasts Inhibition of PTPL1 expression or expression of dominant- negative up-regulates surface Fas levels [59] ↓apoptosis
A549 PTPL1 expression is necessary for inhibition by necl2 of Her2 signaling, cell movement and survival [77] ↑apoptosis
Squamous cell carcinomas of the head and neck PCI-15A Fas resistant Inhibition of PTPL1 expression increases Fas apoptosis [67] ↓apoptosis
early-passage human tonsil epithelial cells Inhibition of PTPL1 expression induces anchorage-independent growth with H-Ras and invasive growth of xenografts. PTPL1 expression reverses anchorage-independent growth in cells lacking PTPL1 [81]
Overexpression of Her2 with shPTPL1 transfection induced Erk1/2 phosphorylation. PTPL1 overexpression inhibited Erk1/2 and Mek1/2 activation induced by H-Ras, Her2 or EGF-Receptor transfection [80]
↓ cell growth ↓ cell invasiveness
Ewing’s Sarcoma Family of Tumors TC71 Reduction of PTPL1 protein levels, using an antisense strategy, leads to reductions in both anchorage-dependent and anchorage-independent cell growth induced by EWS-FLI1[68] ↑cell growth
Kidney HEK293
embryonic cells
Expression of PTPL1 Inhibits LPA induced cell motility [43] ↓ cell invasiveness
HHS Vulnerability Disclosure