Table II.
Heart rate [min−1] before and after metoprolol or 0.9% NaCl intraperitoneal administration (mean±SE) in rats during 4-week administration of simvastatin or placebo
| Metoprolol or 0.9% NaCl injection | |||
|---|---|---|---|
| Before | After | Difference [%] | |
| K_Na (9) | 441.47±5.60 | 445.01±4.53 | 100.84±0.65 |
| K_M (6) | 439.29±14.03 | 374.41±13.32 | 85.27±1.89t |
| S1_ Na (6) | 443.41±13.45 | 448.74±13.78 | 101.21±0.72 |
| S1_M (6) | 429.37±14.46 | 356.97±7.48 | 83.41±2.66t |
| S10_Na (6) | 419.40±10.63 | 418.48±9.93 | 99.81±0.77 |
| S10_M (6) | 481.05±6.60 | 396.63±8.03 | 82.44±0.75t |
| S20_Na (5) | 448.93±19.95 | 448.28±16.52 | 99.95±1.62 |
| S20_M (7) | 436.15±13.84 | 375.66±7.67 | 86.25±1.58t |
K_Na – control group receiving 0.9% NaCl injection, K_M – control group receiving metoprolol injection, S1_Na, S1_M – rats receiving 1 mg/kg simvastatin and 0.9% NaCl or metoprolol injection, S10_Na, S10_M – rats receiving 10 mg/kg simvastatin and 0.9% NaCl or metoprolol injection, S20_Na, S20_M – rats receiving 20 mg/kg simvastatin and 0.9% NaCl or metoprolol injection, (n) – number of rats in group, ‘t’ – p<0.05 t-par