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. Author manuscript; available in PMC: 2012 Mar 21.
Published in final edited form as: Chem Sci. 2011 Jun 10;2(9):1772–1776. doi: 10.1039/C1SC00194A

Table 1.

Optimization of reaction conditions

graphic file with name nihms355844u1.jpg
Entry Conditionsa Yield [%]b
1 20 mol% B, 40 °C, CH2Cl2 Trace
2 20 mol% C, 40 °C, CH2Cl2 4
3 20 mol% A, 40 °C, CH2Cl2 94
4 10 mol% A, 40 °C, CH2Cl2 37
5 20 mol% A, 40 °C, CH3CN 0
6 20 mol% A, 40 °C, THF 50
graphic file with name nihms355844t1.jpg
a

General conditions: vinyl sulfone (1 equiv), nitrone (3 equiv), NaOt-Bu (20 mol%), solvent (0.10 M), 4 Å MS.

b

Yield of isolated products.