Table 4. Brain–blood concordant biomarkers modulated by DHA in (a) female mice and (b) male mice.
|
(a) Females | ||||||||
|---|---|---|---|---|---|---|---|---|
| Gene symbol (name) | AMY and blood change | Animal brain evidence | Animal blood evidence | Animal genetic evidence | Human brain evidence | Human blood evidence | Human genetic evidence | CFG score |
|
RAB27b (member RAS oncogene family) |
D |
(I) Alcohol154 |
|
|
|
|
18q21.2
(linkage)
BP144
MDD119 |
1.0 |
|
Gene symbol (name) |
HIP and blood change |
Animal brain evidence |
Animal blood evidence |
Animal genetic evidence |
Human brain evidence |
Human blood evidence |
Human genetic evidence |
CFG score |
| KLF9 (Kruppel-like factor 9) | D | BP AMY, CP29 Alcohol NAC116 | (QTL) Abnormal circadian rhythm | (D) Alcohol180 | 9q21.12 (linkage) BP147, 215 Alcohol137, 199 | 3.0 | ||
| CAP1 (adenylate cyclase-associated protein 1) | D | (D) Depression216 | (D) BP216 (D) MDD117 (I) MDD79 | 1p34.2 (linkage) Alcohol161 BP217 | 2.0 | |||
| SSX2IP (synovial sarcoma, X breakpoint 2 interacting protein) | D | (D) Alcohol180 | 1p22.3 (linkage) BP217 Alcohol134, 199 Alcohol/depression218 | 1.5 | ||||
| NDUGA5 (NADH dehydrogenase (ubiquinone) Fe-S protein 5) | I | Alcohol NAC116 | 1.0 | |||||
| VPS13A (vacuolar protein sorting 13A) | D | (I) DBP-ST PFC22 (I) Depression102 | 1.0 | |||||
| CAPZB (capping protein (actin filament) muscle Z-line, β) | D | (I) Alcohol154 | 0.5 | |||||
|
GNG2 (guanine nucleotide binding protein (G protein), γ 2) |
D |
|
|
|
|
|
|
0.0 |
|
(b) Males | ||||||||
|
Gene symbol (name) |
PFC and blood change |
Animal brain evidence |
Animal blood evidence |
Animal genetic evidence |
Human brain evidence |
Human blood evidence |
Human genetic evidence |
CFG score |
|
TFRC (transferrin receptor) |
I |
Alcohol CP, HIP116 |
|
|
|
|
3q29
(linkage)
BP219
BP/SZ220
SZ, SZA, BP144
Alcohol161 |
1.5 |
|
Gene symbol (name) |
AMY and blood change |
Animal brain evidence |
Animal blood evidence |
Animal genetic evidence |
Human brain evidence |
Human blood evidence |
Human genetic evidence |
CFG score |
| CD24A (CD24a antigen) | I | (D) DBP-ST AMY22 | BP30 | 2.0 | ||||
|
FTL1 (ferritin light chain 1) |
I |
(D) DBP-ST AMY; (D) DBP-ST PFC22
Alcohol NAC116 |
|
|
|
|
|
1.0 |
|
Gene symbol (name) |
HIP and blood change |
Animal brain evidence |
Animal blood evidence |
Animal genetic evidence |
Human brain evidence |
Human blood evidence |
Human genetic evidence |
CFG score |
| GLUL (glutamate-ammonia ligase) | I | (I) Stress158 BP PFC, VT29 Alcohol AMY, NAC116 | BP30 | (QTL) Abnormal emotion/affect behavior, addiction/drug abuse | (D) MDD159, 160 (D) Suicide-MDD41, 143 | 1q25.3 (linkage) Alcohol161 | 4.0 | |
| LIMD2 (LIM domain containing 2) | D | BP30 | 1.0 | |||||
| TTR (transthyretin) | D | BP CP29 (I) Anxiety/depression148 (I) Anxiety49, 142 (I) Depression221 | 1.0 | |||||
| PSME4 (proteasome (prosome, macropain) activator subunit 4) | I | 0.0 | ||||||
Abbreviations: AMY, amygdala; BP, bipolar; CFG, convergent functional genomics; CP, caudate putamen; D, decreased in expression; DHA, docosahexaenoic acid; HIP, hippocampus; I, increased in expression; MDD, major depressive disorder; NAC, nucleus acumbens; NST, non-stressed; PFC, prefrontal cortex; PPD, postpartum depression; QTL, quantitative trait locus; ST, stressed; SZ, schizophrenia; SZA, schizoaffective disorder; VT, ventral tegmentum.