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. 2011 Nov 22;1(11):e56. doi: 10.1038/tp.2011.54

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Copyright © 2011 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Brain-derived neurotrophic factor (BDNF), Wnt2 and 15-Deoxy-delta12,14-prostaglandin J2 (15d-PGJ2) are secreted by serotonergic neurons in response to fluoxetine and are increased in cerebrospinal fluid (CSF) of mice or depressed patients following fluoxetine treatment. (a–c) Treatment of 1C11^5−HT cells with fluoxetine (50 n, 2 days) induced the release of BDNF (a), Wnt2 (b) and 15d-PGJ2 (c) (n=6). (d–i), Treatment of mice (d–f) or depressed patients (g–i) with fluoxetine induced an increase of BDNF (d, g), Wnt2 (e, h) and 15d-PGJ2 (f, i) in CSF. The values are the means±s.e.m (n=5 for mice, n=7 for patients), ^*P<0.01 vs control.