Table 2. Antidepressant drug target candidates that are regulators and targets of altered metabolites, expression analysis systematic explorer (EASE), score<0.05.
| Pathway cluster | Antidepressant drug target candidate | Category | P-value | EASE score |
|---|---|---|---|---|
| Carbohydrate metabolism | ATP-dependent hexokinase | Functional class | 0.005 | 0.033 |
| -fructose 1,6-diphosphatase | Functional class | 4.1E-04 | 0.012 | |
| FBP1 (fructose bisphosphatase 1) | Protein | 0.004 | 0.042 | |
| GCK (glucokinase) | Protein | 8.8E-05 | 0.001 | |
| glucose transporter | Functional class | 0.002 | 0.021 | |
| GYS2 (glycogen synthase 2) | Protein | 0.001 | 0.008 | |
| HK1 (hexokinase 1) | Protein | 1.5E-04 | 0.006 | |
| HK2 (hexokinase 2) | Protein | 7.5E-05 | 0.004 | |
| MPI (mannose phosphate isomerase) | Protein | 1.5E-04 | 0.006 | |
| Amino acid metabolism | 3-Methyl-2-oxobutanoate dehydrogenase | Functional class | 0.002 | 0.033 |
| aa (amino acid) import | Cellular process | 0.005 | 0.048 | |
| Glutamate dehydrogenase | Functional class | 0.004 | 0.030 | |
| Hormone signaling | AGT (angiotensinogen) | Protein | 0.012 | 0.047 |
| DPP4 (dipeptidyl-peptidase 4) | Protein | 1.5E-04 | 0.006 | |
| GCG (glucagon) | Protein | 0.004 | 0.021 | |
| INS (insulin) | Protein | 0.003 | 0.013 | |
| Other | Uchl1 (ubiquitin carboxyl-terminal esterase L1) | Protein | 0.002 | 0.032 |