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. 2011 Jul 26;1(7):e23. doi: 10.1038/tp.2011.25

Figure 2.

Figure 2

Involvement of corticotropin-releasing factor (CRF) in cancer anorexia. (a) The serotonin (5-HT)-induced cytosolic Ca2+ concentration ([Ca2+]i) increase was suppressed by rikkunshito in single CRF neurons isolated from the paraventricular nucleus (PVN). (b) Inhibitory effect of CRF on plasma acyl ghrelin concentrations in fasted rats (n=8–9). (c) Inhibitory effects of ghrelin and rikkunshito on the efferent activity of the adrenal sympathetic nerve in rats. (d) Food intake was increased in tumor-bearing rats by daily administration of the CRF receptor antagonist α-helical CRF (n=9–10). (e) Plasma corticosterone concentration of tumor-bearing rats (n=12). (f) Hypothalamic CRF levels in tumor-bearing rats were decreased by SB242084 or rikkunshito (n=10). (g) Daily administration of rikkunshito in tumor-bearing rats improved rearing and decreased fecal pellet output score in an open-field test (n=9–10). *P<0.05; **P<0.01. DW: distilled water.