Table 1. Main activations to happy and fearful versus neutral faces.
|
MNI coordinates |
P-value (FWE-corrected) | Z-score | Cluster size | Region | ||
|---|---|---|---|---|---|---|
| x | y | z | kE (voxels) | |||
| Happy versus neutral faces | ||||||
| Control group | ||||||
| −28 | 10 | 54 | 0.002 | 5.07 | 129 | Left superior frontal gyrus |
| 46 | 20 | −16 | 0.003 | 4.90 | 78 | Right temporal pole |
| −42 | 14 | −16 | 0.004 | 4.86 | 200 | Left temporal pole |
| −36 | −62 | 24 | 0.006 | 4.76 | 77 | Left temporoparietal junction |
| −54 | −64 | 10 | 0.009 | 4.66 | 115 | Left posterior STS |
| 44 | −52 | −28 | 0.010 | 4.65 | 60 | Right FFA |
| −4 | 26 | 54 | 0.012 | 4.60 | 64 | Left dorsomedial prefrontal cortex |
| 66 | −28 | 2 | 0.015 | 4.54 | 32 | Right middle STS |
| 28 | −92 | 8 | 0.018 | 4.51 | 26 | Right cuneus |
| −62 | −52 | 4 | 0.026 | 4.41 | 26 | Left middle STS |
| −24 | −94 | 8 | 0.031 | 4.37 | 20 | Left cuneus |
| Sibling group | ||||||
| Nil | ||||||
| Autism group | ||||||
| Nil | ||||||
| Fearful versus neutral faces | ||||||
| Control group | ||||||
| 44 | −48 | −22 | 0.006 | 4.78 | 38 | Right FFA |
| Sibling group | ||||||
| 40 | −42 | −16 | 0.005 | 4.80 | 33 | Right FFA |
| Autism group | ||||||
| Nil | ||||||
Abbreviations: FFA, fusiform face area; FWE, family-wise error; MNI, Montreal Neuroimaging Institute; STS, superior temporal sulcus.
Activated brain regions, corresponding MNI coordinates, cluster sizes, Z-scores and P-values. All analyses are corrected for multiple comparisons, and P-values are expressed following whole brain level FWE correction at the threshold of P<0.05.