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. 2011 Jul 5;1(7):e17. doi: 10.1038/tp.2011.14

Table 2. Raw and permuted P-values from family-based association tests using the VAS-P score and the severity of symptoms derived using latent class analyses, as qualitative and quantitative traits, respectively.

Marker Gene Allele Frequency Effect Score
 Severity
          Inattention H/I ODD CD A/D Inattention H/I ODD A/D
Chromosome 4
 rs1947275 LPHN3 C 0.814 + 0.00819a                
 rs2132074 LPHN3 G 0.618 +     0.0017a            
 rs4552500 LPHN3 G 0.608 +     0.0031b            
 rs13124636 LPHN3 G 0.046 −     0.0414b            
 rs4860091 LPHN3 T 0.386 +       0.0054b          
 rs335322 LPHN3 G 0.575 +       0.007b          
 rs10015239 LPHN3 A 0.577 +       0.0098b          
 rs35106420 LPHN3 G 0.985 +         0.0154b        
 rs12646895 LPHN3 G 0.508 +         0.0019b        
 rs1510920 LPHN3 C 0.061 +         0.0368b        
 rs186750 LPHN3 A 0.243 +         0.0216b        
 rs734644 LPHN3 T 0.271 +               0.0117b  
 rs6813183 LPHN3 G 0.300 +               0.0114b  
 rs6551670 LPHN3 A 0.300 +               0.0105b  
 rs6551669 LPHN3 C 0.300 +               0.0105b  
                           
Chromosome 5
 rs249637 NDFIP1 G 0.074 − 0.0216b                
 rs37022 SLC6A3 T 0.831 +   0.0052a              
 rs250682 SLC6A3 C 0.798 +   0.0082b              
 rs6596271 SLC25A48 G 0.042 −         0.0052b        
 rs164080 GNPDA1 C 0.526 +                 0.0015b
                           
Chromosome 11
 rs10891551 DRD2 A 0.122 + 0.0253b                
 rs719804 TTC12 G 0.223 − 0.0117b                
 rs4938006 NCAM1/TTC12 G 0.109 +     0.034b 0.0106a         0.0359a,c
 rs12799083 DRD2 C 0.031 −       0.0107b          
 rs4245148 DRD2 T 0.122 +       0.0251b          
 rs17596017 NCAM1 T 0.024 −         0.0191b        
 rs1381246 BSX C 0.451 −         0.0057b        
 rs652285 NCAM1 T 0.057 +           0.0097b 0.0082b   0.0214b
 rs675646 NCAM1 C 0.071 +           0.0107b 0.0807b   0.0105a
 rs649568 NCAM1 T 0.044 +           0.0171b     0.0162b
 rs702966 PHRF1 C 0.276 −           0.0121b      
 rs2574829 NCAM1 G 0.394 +             0.0084b    
 rs11214521 NCAM1 G 0.035 −               0.0226  
 rs11214505 NCAM1 G 0.082 −               0.0292  
 rs1055076 TTC12 A 0.175 +               0.0343  
 rs12222469 NCAM1 A 0.035 +                 0.0183b
                           
Chromosome 12
 rs17722134 TPH2 G 0.029 −         0.0085b        
                           
Chromosome 17
 rs7208257 ARRB2 C 0.055 +     0.0164b            

Abbreviations: A/D, anxiety and depression; CD, conduct disorder; H/I, hyperactivity/impulsivity; ODD, oppositional defiant disorder; VAS-P, Vanderbilt Assessment Scale for Parents.

Nonsignificant P-values after B=10,000 permutations are shown in italic.

No correction for the number of questions interrogated was performed in genetic association analyses.

a

Permutated P-value <0.01.

b

Permutated P-value <0.05.

c

Effect on the severity towards opposite direction to the one described in the ‘effect' column.