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. 2012 Feb 7;2(2):e77. doi: 10.1038/tp.2012.2

Figure 4.

Figure 4

Serotonin system characteristics associated with the rh5-HTTLPR short allele in PBCs. Experimental data from S/L and S/S genotypes were merged and means±s.e.m.s are shown for (a) maximal serotonin uptake, (b) maximal surface SERT binding, (c) SERT mRNA levels, (d) 5-HT concentrations, (e) 5-HIAA concentrations and (f) 5-HIAA to 5-HT ratios. Data for animals having one or two ‘S' alleles (S/L and S/S) were compared with data from animals with the L/L genotype using one-tailed t tests (t=3.6, df=13, P<0.01 for maximal serotonin uptake, t=2.3, df=13, P<0.05 for maximal SERT binding) or two-tailed t tests (t=3.7, df=11, P<0.01 for 5-HIAA concentrations, and t=3.0, df=11, P<0.05 for 5-HIAA/5-HT ratios). Individual values for each animal are shown as scatter plots overlaid on the respective bar graphs. Data are means±s.e.m.s with N=5–6 for L/L and N=8–9 for ‘S' genotypes. **P<0.01 and *P<0.05 vs the L/L genotype.