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. 2012 Feb 28;2(2):e85. doi: 10.1038/tp.2012.7

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Copyright © 2012 Macmillan Publishers Limited

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Chromosome X region (top) containing the genotyped single-nucleotide polymorphisms (SNPs) with corresponding linkage disequilibrium (LD) values. The variable number of tandem repeats (VNTR) previously shown to regulate MAOA activity is located approximately 1000 bases upstream of the MAOA transcription start site. Protein-coding exons are depicted as vertical lines and the 5′ and 3′ untranslated regions as filled black boxes. Rs6609257, significantly associated to visuospatial working memory (VSWM) after Bonferroni correction in this study, is highlighted in bold. The bottom panel shows the calculated LD between pairs of SNPs as percentage of the theoretical maximal LD with logarithm of likelihood odds ratio (D'/LOD) using Haploview 4.2. All SNPs are in high or complete LD with statistical significance. Values are based on our own ‘Brainchild' sample set. Black squares without text depict complete (100%) LD.