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. 2011 Dec 15;3(3):186–192. doi: 10.1021/cn200103n

Table 2. Conventional Mutations of Other Aromatic Residues in or close to the Binding Pocket^a.

	Y106		F138		Y167		Y200		Y208		W246		Y251
	EC₅₀ (μM)	nH	EC₅₀ (μM)	nH	EC₅₀ (μM)	nH	EC₅₀ (μM)	nH	EC₅₀ (μM)	nH	EC₅₀ (μM)	nH	EC₅₀ (μM)	nH
F	1.9 ± 0.4	1.5 ± 0.3	1.4 ± 0.2	1.6 ± 0.3	1.1 ± 0.2	1.1 ± 0.2	110 ± 34^b	1.2 ± 0.3	1.5 ± 0.1	1.7 ± 0.2	2.9 ± 0.6	1.4 ± 0.2	1.4 ± 0.3	1.6 ± 0.2
A	8.1 ± 1.2^b	1.4 ± 0.2	62 ± 12^b	1.1 ± 0.2	23 ± 2^b	1.4 ± 0.2	NR		NR		0.95 ± 0.09	1.1 ± 0.2	1.2 ± 0.3	1.7 ± 0.3
S	5.7 ± 0.9^b	1.7 ± 0.4	54 ± 4^b	1.7 ± 0.1	4.3 ± 0.5^b	1.5 ± 0.2	NR		2.0 ± 0.1	2.2 ± 0.3	1.4 ± 0.04	2.4 ± 0.1	3.9 ± 0.2^b	2.4 ± 0.2

^a

Data = mean ± SEM, n = 3–5.

^b

Significantly different, p < 0.05.