Table 2.

Fallopian tube origin of Dicer-Pten DKO serous carcinomas

	Ovary removal		Fallopian tube removal
	Unilateral	Bilateral	Unilateral	Bilateral
Total no. of DKO mice	11	11	10	17
No. of DKO mice with tumor	10*	8†	9‡	0
% of mice with tumor	90.9a	72.7a	90a	0b
Age at death, mo	6–13	7–13	6–13	—
Current age of live mice, mo	—	15	16	14–16

Ovaries or fallopian tubes were surgically removed unilaterally or bilaterally from Dicer-Pten DKO mice at 6–11 wk of age and examined for tumor development. Fisher's exact test was used to analyze the statistical significance in different tumor occurrences between groups. Different letters indicate statistically significant difference between groups (P < 0.0001); same letters no significant difference.

*One other mouse also died after developing tumor, but no tumor was found from the side where the ovary was removed; thus, it was not counted as tumor development.

^†Three live mice were sacrificed at 15 mo. All three mice had fallopian tube tumors; one of these mice also had peritoneal metastases with accumulating ascites.

^‡Despite tumor development from the side with intact ovary and fallopian tube, no tumor was observed on the other side after fallopian tube removal—with ovary alone.