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. 2012 Feb 10;109(10):E605–E612. doi: 10.1073/pnas.1110666109

Fig. 5.

Fig. 5.

(A–E) Eye morphology of (A) GMR-GAL4/+ control flies and those expressing (B) full-length Relish (C), C-terminal domain (D) or the N-terminal domain using the GMR-GAL4 driver. (E) Eye depicting the effect of increased dosage of NTD in the photoreceptors, accomplished by two copies of the UAS-NTD transgene using the GMR-GAL4 driver. (Scale bar, 150 μm.) (F) MS1096-GAL4-driven expression of full-length Relish, CTD or the NTD in the developing wing. Wing of MS1096-GAL4/+ driver line included as a control. (Scale bar, 1 mm.) (G–J) Effect of NTD expression in adult photoreceptors. (G) UAS-NTD tubGAL80(ts) flies were reared at 30 °C for 4 wk and served as a control in this experiment. (H) Retinal degeneration was evident after 1 wk at 30 °C in UAS-NTD GAL80(ts)/LGMR-GAL4 flies. Extending the time period to (I) 2 wk or (J) 4 wk exacerbated the retinal degeneration. (Scale bar, 20 μm.)