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F8−/− does not rescue the embryonic lethality of Tfpi−/− mice. A total of 445 pups was genotyped from breeding of Tfpi+/−;F8−/− male and female mice, with a range of 21 to 67 pups on each embryonic day. The expected survival of Tfpi−/− mice from this mating is 25%, if no embryonic death occurs. There is no difference in embryonic survival between Tfpi−/−;F8−/− mice (■) and Tfpi−/−;F8+/+ mice (●), originally published by Huang and coworkers (21).
