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. 2012 Feb 21;109(10):3927–3931. doi: 10.1073/pnas.1119858109

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Fig. 2. — Tfpi^+/− does not alter the bleeding phenotype of F8^−/− mice. (A) The TEG R value (time for clot initiation) was significantly prolonged in F8^−/− mice (▲) compared with F8^+/+ mice (◆) (P = 0.0026) or Tfpi^+/− mice (▼) (P = 0.018), but the presence of Tfpi^+/− in F8^−/− mice (■) did not decrease this prolongation (P = 0.59). (B) The TEG α angle (a measure of the kinetics of fibrin formation) was significantly decreased in Tfpi^+/−;F8^−/− mice (■) compared with Tfpi^+/− mice (▼) (P = 0.017), but Tfpi^+/−;F8^−/− mice (■) were not different from F8^−/− mice (▲) (P = 1). (C) In the 1-mm clip tail bleeding model, F8^−/− mice (▲) showed a trend to bleed more than F8^+/+ mice (◆) but it was not statistically significant (P = 0.23), whereas Tfpi^+/−;F8^−/− mice (■) had essentially identical blood loss as F8^−/− mice (▲) (P = 1). Similarly, there was no difference between Tfpi^+/− (▼) and Tfpi^+/+ (◆) mice.