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. 2012 Feb 6;109(10):E613–E621. doi: 10.1073/pnas.1115029109

Fig. 6.

Fig. 6.

EMSY represses the expression of ISGs in human mammary and ovarian carcinoma cell lines, and repression is relieved via phosphorylation at Ser209. (A) Expression of the indicated ISGs was measured by real-time RT-PCR in MDA MB 231, OVCAR3, and OVCAR4 cells transduced with a lentiviral construct of shEMSY or EV. Error bars show the SD (n = 3). (B) Expression of the indicated ISGs was measured by real-time RT-PCR in MDA MB 231, OVCAR3, and OVCAR4 cells transduced with pLenti constructs expressing WT EMSY, EMSY S209A, or EV. As in A, the bars show fold repression and the error bars show the SD (n = 3). Con, control. (C) Expression of the indicated ISGs was measured by real-time RT-PCR in MDA MB 231 cells transduced with lentiviral constructs of shAkt1, shAkt2, or EV. As in A and B, the bars show fold repression and the error bars show the SD (n = 3).