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Contribution of SR function to Ca2+ transients. (A) Steady-state Ca2+ transients in cardiomyocytes field stimulated (6 Hz) before and during presence of 10 mM caffeine. Histogram: Mean values of the Ca2+ transient magnitudes (n = 17–19). (B) Contribution of SR function to Ca2+ transient magnitude derived from experiments in A. (C) SR Ca2+ content measured as peak caffeine-elicited Ca2+ transient (n = 18–19).
