Fig. 1.

In vivo evaluation of medulloblastoma dissemination and disease progression. Bioluminescence images from mice containing D283Luc tumors. Animals were implanted with D283luc cells in the right lateral ventricle. Bioluminescence imaging was conducted 3, 7, 14, and 21 days following tumor implantation. Bioluminescent signals in the brain and spinal cord are visible as early as 3 days following tumor implantation. Tumor burden in the brain and spinal cord, as determined by total flux (photons/s), increased steadily over time. Animals not displaying a bioluminescent signal in their spinal cord at day 3 failed to exhibit a signal throughout the course of the study and were excluded from the study (data not shown).