Fig. 4.

Antitumor effect of measles virus (MV). D283luc medulloblastoma cells were injected into the right lateral ventricle of female athymic nude mice. Fourteen days (A) or 3 days (B) post tumor implantation the mice received a total of 1 × 10⁶ pfu of MV or the same dose of UV-MV. Mice treated with MV had significantly longer survival than mice that received UV-MV (P < .002 (A); P < .0005 (B)). Mice treated with MV 14 days after tumor implantation had a median survival time of 49 days compared to 40 days exhibited by the UV-MV mice. Likewise, mice treated with MV-GFP 3 days after tumor implantation had a median survival time of 80 days, whereas the UV MV-GFP mice had a median survival time of only 37 days. (C) A similar experiment also demonstrated significant (P < .0001) survival of mice treated with MV 3 days following D425luc implantation when compared to mice that received UV-MV-GFP. D425luc xenografts treated with MV had a median survival time of 37.5 compared to 16 days for xenografts treated with UV-MV.