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. 2012 Feb 29;14(4):440–458. doi: 10.1093/neuonc/nos001

Fig. 8.

Fig. 8.

CCT007093 inhibits growth of WIP1 high-expressing medulloblastoma cells. (A) Representative photomicrographs of D556-WIP1 (Clone 2-1F) cells 6 days after treatment with vehicle or with the WIP1 small molecule inhibitor CCT007093 (Mag. 4×). Bars measure 500 μm. (B) Viability of D556-WIP1 (Clone 2-1F) and D556-WIP1 D314A (Clone 1D) cells, determined by trypan blue exclusion, 6 days following treatment with vehicle or with 0.5–5 μM CCT007093 (*P < .0005 at both doses). Error bars represent standard deviation among triplicates. (C) Western blotting of whole cell lysates of D556-WIP1 (Clone 2-1F) and D556-WIP1 D314A (Clone 1D) cells 72 h following treatment with vehicle or with 5 μM CCT007093. All experiments were repeated at least 3 times.