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Top. Measurement of the mean tumor diameter (MTD). The 3 largest tumor diameters in 3 orthogonal planes (axial, coronal, and sagittal) were manually measured. The tumor volume (V) was calculated by an ellipsoid approximation (V = (D1 × D2 × D3)/2), and the MTD was deduced from the volume (MTD = (2 × V)1/3 Bottom. Examples of the evolution of the VDE following RT. The mean tumor diameter (mm) is plotted over time (years).
