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. 2011 Oct 21;67A(4):313–329. doi: 10.1093/gerona/glr164

Figure 1.

Figure 1.

A: Serum insulin-like growth factor (IGF)-1 protein levels in mice with hepatic IGF-1 knockdown (Igf1f/f + MUP-iCre-AAV8, initiated at 5 months of age and assessed at 11 months of age) and control (Igf-1f/f + MUP-eGFP-AAV8) mice. Data are mean ± SEM. *p < .05 versus control (n = 20 in each group). B: Acetylcholine induced relaxation of aorta rings isolated from IGF-1–deficient and control mice. Data are mean ± SEM (n = 4 in each group). C: Production of H2O2 in the aortas of IGF-1–deficient and control mice as assessed by Amplex Red/horseradish peroxidase assay. Data are mean ± SEM (n = 6 in each group). GSH (D) and ascorbate (E) content, determined using high-performance liquid chromatography electrochemical detection, in the aorta of IGF-1–deficient and control mice. Data are mean ± SEM (n = 10 in each group).