Table 2.

Linear Regression Models of the Association of Leukocyte Telomere Length to Physiologic Index Score

	Age itself*		Index itself*		Model 1†		Model 2‡		Model 3§		Model 4‖
Covariate	β (SE)	p	β (SE)	p	β (SE)	p	β (SE)	p	β (SE)	p	β (SE)	p
Index score, 1 SD			−183(38)	<0.001	−132 (42)	<0.001	−130 (45)	<0.01	−124 (46)	<0.01	−132 (47)	<0.01
Age, 1 SD	−165(39)	<0.001			−102 (44)	0.02	−106 (45)	0.02	−111 (46)	0.02	−107 (46)	0.02
Male gender					−123 (77)	0.11	−118 (78)	0.13	−128 (80)	0.11	−122 (80)	0.13
Black race					73 (111)	0.51	92 (115)	0.42	88 (115)	0.45	84 (115)	0.47
Behavioral risk factors
Education less than college							0 (78)	0.99	−4 (79)	0.96	−12 (81)	0.88
Body mass index, 1 SD							−9 (40)	0.82	−9 (42)	0.83	−15 (43)	0.73
Current smoking status							−36 (129)	0.78	−46 (131)	0.72	−45 (131)	0.73
Inflammation and coagulation markers
ln(CRP), 1 SD									−61 (44)	0.17	−65 (44)	0.14
Fibrinogen, 1 SD									41 (46)	0.37	44 (46)	0.34
No. of diagnosed chronic health conditions, 1 point											33 (42)	0.43

Notes: CRP = C-reactive protein.

^*Unadjusted. The difference in base pairs in mean leukocyte telomere length given a 1 SD higher continuous covariate or the presence of a categorical covariate.

^†Adjusted for age, gender, and race.

^‡Additionally adjusted for education, body mass index, and current smoking status.

^§Additionally adjusted for ln(CRP) and fibrinogen.

^‖Additionally adjusted for number of diagnosed chronic health conditions.