Table 1.

Hazard Ratios of Common Age-Related Diseases for Centenarians and Their Siblings Stratified by Age Versus Controls (lines 1–4) and for Centenarians Versus Nonagenarians, Semisupercentenarians Versus Centenarians, and Supercentenarians Versus Semisupercentenarians (lines 5–7)

	Cancer		CVD		Dementia		Hypertension		Osteoporosis		Stroke
	Est	95% CI	Est	95% CI	Est	95% CI	Est	95% CI	Est	95% CI	Est	95% CI
HR (nonagenarians vs controls)	0.12	0.09–0.17	0.55	0.40–0.76	0.65	0.35–1.31	0.17	0.13–0.22	0.41	0.30–0.56	0.22	0.14–0.36
HR (centenarians vs controls)	0.09	0.07–0.12	0.38	0.29–0.49	0.36	0.20–0.71	0.13	0.10–0.15	0.30	0.23–0.39	0.14	0.10–0.21
HR (semisupercentenarians vs controls)	0.08	0.06–0.11	0.26	0.19–0.34	0.21	0.11–0.44	0.11	0.09–0.14	0.27	0.21–0.36	0.07	0.05–0.11
HR (supercentenarians vs controls)	0.06	0.05–0.09	0.18	0.13–0.26	0.10	0.05–0.23	0.08	0.06–0.11	0.17	0.12–0.25	0.05	0.03–0.09
HR (centenarians vs nonagenarians)	0.79	0.57–1.07	0.68	0.53–0.89	0.56	0.39–0.80	0.74	0.58–0.95	0.73	0.56–0.95	0.63	0.43–0.93
HR (semisupercentenarians vs centenarians)	0.85	0.70–1.04	0.68	0.56–0.83	0.59	0.45–0.77	0.90	0.76–1.07	0.91	0.75–1.11	0.54	0.40–0.71
HR (supercentenarians vs semisupercentenarians)	0.81	0.59–1.09	0.71	0.53–0.95	0.49	0.31–0.76	0.70	0.53–0.91	0.62	0.45–0.85	0.73	0.49–1.07

Notes: Diseases and ages of onset are based on medical history and annual follow-up data. Cancer includes all cancers except skin cancers. Cardiovascular disease (CVD) is defined as angina pectoris, cardiac arrhythmia, congestive heart failure, and/or myocardial infarction. Osteoporosis is defined as diagnosis or fracture of wrist, femur, or spine. Estimates (Est) and 95% credible intervals (95% CI) were computed as the median, 2.5 and 97.5 percentiles from at least 20,000 samples generated from the posterior distribution of the parameters. The time of event was modeled using Weibull regression as described in the methods. HR = hazard ratio.