Fig. 1.

Phylogenetic analysis of sponge cryptochromes (Amphimedon queenslandica Aq-Cry1 and Aq-Cry2), cnidarian cryptochromes/photolyases and previously defined major clades of the cryptochrome/photolyase family. We selected representatives of major clades (in red) and used them as ‘bait’ to find similar sequences in UniRef databases. We next aligned together all poriferan, cnidarian, database-retained and bait sequences using MUSCLE. Then we estimated maximum likelihood phylogenetic trees using 10 Slow ML searches in RAxML, assuming a WAG model of protein evolution. Numbers at nodes represent percentages of 100 fast-bootstrap pseudoreplicates containing that node. CPD, cyclobutane pyrimidine dimer.