. 2012 Mar 21;18(11):1208–1215. doi: 10.3748/wjg.v18.i11.1208

Table 3.

Expression of immunoreactive HER2, bradykinin B₁ receptor and Ki-67 in gallbladder adenomas and in adenocarcinoma and its putative precursor lesions (%)

Receptor/marker	Normal epithelium	Pyloric adenoma	Intestinal adenoma	Intestinal metaplasia	Carcinoma in situ	Invasive carcinoma
HER2	0/5	0/14	1/6 (17)	22/24 (91.7)^a	9/10 (90)^a	4/12 (33)
Bradykinin B₁R	0/5	10/15 (67)^a	6/6 (100)^a	24/24 (100)^a	10/10 (100)^a	1/12 (8.3)
Ki-67¹	0.05 ± 0.005 (1.1)	0.05 ± 0.01 (5.1)	0.10 ± 0.01 (10.8)	0.36 ± 0.03^b (36.7)	0.37 ± 0.05^b (37.5)	0.42 ± 0.03^b (42)

Proliferation index estimated as immunoreactivity to Ki-67 antigen.

P < 0.05,

P < 0.01 vs normal epithelium. B₁R: B₁ receptor.