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. 2012 Mar 21;7(3):e33889. doi: 10.1371/journal.pone.0033889

Figure 7. PIKfyve inhibition results in depression of hippocampal basal synaptic transmission.

Figure 7

(A) Basal synaptic transmission was recorded in the CA1 region of hippocampal slices. Control (non-treated) hippocampi, or hippocampi treated with DMSO showed stable evoked responses throughout the 210 min recording period. Treatment with the PIKfyve inhibitor (YM201636) elicited a depression of evoked responses that became evident 40 min after drug application. Line-breaks indicate changes in time-scale. Black bar indicates DMSO or drug application. (B) Analog traces representing evoked potentials obtained in control slices or in slices in the presence of DMSO or YM201636, at the time-points indicated in the graph. Vertical scale-bar, 3 mV; horizontal bar, 3 ms.