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. 2012 Mar 22;5:36. doi: 10.3389/fnmol.2012.00036

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Copyright © 2012 Bronicki and Jasmin.

This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited.

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A model illustrating post-transcriptional regulation of AChE expression and localization in neurons by trans-acting factors. (A) Alternative splicing of AChE pre-mRNA is controlled by SC35 and ASF/SF2 general splicing factors. As part of a ribonucleoprotein particle (RNP), nELAVs might also bind to cis-elements within the AChE pre-mRNA to regulate alternative splicing. (B) AChE mRNA is stabilized by HuD and possibly other nELAVs. Stabilization of AChE mRNA could depend on nELAVs outcompeting destabilizing RBPs and/or RISC loaded miR-132, thereby preventing exosome-mediated mRNA degradation. (C) RNPs, conceivably containing nELAVs and Pumilio 2 (Pum2), transport translationally repressed AChE transcripts along microtubules into neurites. (D) At the synaptic terminal, AChE translation might be promoted by nELAVs or inhibited by Pum2 or RISC loaded miR-132.