Table 5. Genotype-phenotype associations of the PTPN2 SNP rs2542151 in CD patients.
| PTPN2 SNP rs2542151 | TT (n = 611) | TG (n = 258) | GG (n = 36) | PG | ORG [95% CI] |
| Age at diagnosis (yr) (n = 817) | |||||
| Mean ± SD | 25.32±11.91 | 28.06±13.48 | 25.19±9.61 | 5.96×10−2 | 0.75 |
| Range | 1–71 | 2–78 | 15–49 | [0.56–1.01] | |
| Age at diagnosis (n = 817) | |||||
| < = 16 years (A1) | 126 (22.7%) | 38 (16.1%) | 4 (14.8%) | 4.53×10−2 | 0.67 [0.45–0.99] |
| (n = 168) | (A1 vs. A2) | ||||
| 17–40 years (A2) | 368 (66.4%) | 161 (68.2%) | 22 (81.5%) | 0.285 | 0.79 [0.50–1.22] |
| (n = 551) | (A2 vs. A3) | ||||
| >40 years (A3) | 60 (10.8%) | 37 (15.7%) | 1 (3.7%) | 1.89×10−2 | 0.53 [0.31–0.90] |
| (n = 98) | (A1 vs. A3) | ||||
| Location (n = 770) | |||||
| Terminal ileum (L1) (n = 113) | 73 (14.3%) | 33 (14.4%) | 7 (21.9%) | 0.715 | 1.08 [0.71–1.64] |
| Colon (L2) | 62 (12.2%) | 31 (13.5%) | 4 (12.5%) | 0.627 | 1.17 |
| (n = 97) | [0.72–1.74] | ||||
| Ileocolon (L3) | 366 (71.9%) | 163 (71.2%) | 21 (65.6%) | 0.682 | 0.93 |
| (n = 550) | [0.67–1.30] | ||||
| Upper GI (L4) | 8 (1.6%) | 2 (0.9%) | 0 (0%) | 0.360 | 0.48 |
| (n = 10) | [0.10–2.29] | ||||
| Behaviour (n = 747) | |||||
| Non-stricturing/Non-penetrating (B1) | 111 (24.3%) | 49 (23.6%) | 12 (42.9%) | 0.645 | 1.08 |
| (n = 172) | [0.76–1.55] | ||||
| Stricturing (B2) | 123 (27.0%) | 57 (27.4%) | 7 (25.0%) | 0.941 | 1.01 |
| (n = 187) | [0.71–1.44] | ||||
| Penetrating | 222 (48.7%) | 102 (49.0%) | 9 (32.1%) | 0.729 | 0.95 |
| (B3) (n = 333) | [0.70–1.29] | ||||
| Use of immunosuppressive agents | no: 65 (16.6%) | 35 (20.3%) | 5 (22.7%) | 0.237 | 0.77 |
| (n = 585) | yes: 326 (83.4%) | 137 (79.7%) | 17 (77.3%) | [0.50–1.19] | |
| Surgery because of CD | no: 265 (48.7%) | 106 (44.7%) | 19 (59.4%) | 0.547 | 1.09 |
| (n = 813) | yes: 279 (51.3%) | 131 (55.3%) | 13 (40.6%) | [0.82–1.47] | |
| Fistulas | no: 290 (52.3%) | 121 (50.2%) | 18 (56.3%) | 0.699 | 1.06 |
| (n = 827) | yes: 264 (47.7%) | 120 (49.8%) | 14 (43.8%) | [0.79–1.42] | |
| Stenosis | no: 234 (42.0%) | 90 (37.5%) | 16 (50.0%) | 0.404 | 1.13 |
| (n = 829) | yes: 323 (58.0%) | 150 (62.5%) | 16 (50.0%) | [0.84–1.53] |
PG: p-value for association comparing carriers of the G-allele to individuals homozygous for T. Association results for age at diagnosis are based on median split. Uncorrected p-values<0.05 are depicted in bold. None of the p-values remained significant after Bonferroni correction for multiple testing (number of hypothesis tested: n = 15, resulting in a significance threshold of p<3.33×10−3).