Table 6. Genotype-phenotype associations of the PTPN2 SNP rs7234029 in CD patients.
| PTPN2 SNP rs7234029 | AA (n = 612) | AG (n = 253) | GG (n = 32) | PG | ORG [95% CI] |
| Age at diagnosis (yr) (n = 811) | |||||
| Mean ± SD | 25.80±12.36 | 26.77±12.40 | 25.73±12.52 | 0.197 | 0.82 |
| Range | 1–71 | 6–78 | 12–64 | [0.61–1.11] | |
| Age at diagnosis (n = 811) | |||||
| < = 16 years (A1) (n = 168) | 124 (22.5%) | 36 (15.3%) | 8 (30.8%) | 4.25×10−2 | 0.67 [0.46–0.99] (A1 vs. A2) |
| 17–40 years (A2) (n = 546) | 357 (64.9%) | 173 (73.6%) | 16 (61.5%) | 0.271 | 1.30 [0.81–2.09] (A2 vs. A3) |
| >40 years (A3) (n = 97) | 69 (12.5%) | 26 (11.1%) | 2 (7.7%) | 0.637 | 0.87 [0.50–1.53] (A1 vs. A3) |
| Location (n = 764) | |||||
| Term. ileum (L1) (n = 113) | 76 (14.8%) | 29 (12.6%) | 8 (38.1%) | 0.978 | 0.99 [0.65–1.52] |
| Colon (L2) (n = 96) | 64 (12.5%) | 30 (13.0%) | 2 (9.5%) | 0.915 | 1.03 [0.65–1.61] |
| Ileocolon (L3) (n = 545) | 364 (71.0%) | 170 (73.9%) | 11 (52.4%) | 0.740 | 1.06 [0.76–1.48] |
| Upper GI (L4) (n = 10) | 9 (1.8%) | 1 (0.4%) | 0 (0%) | 0.157 | 0.22 [0.03–1.78] |
| Behaviour (n = 686) | |||||
| Non-stricturing -Non-penetrating (B1) (n = 170) | 116 (25.4%) | 49 (23.0%) | 8 (42.1%) | 0.682 | 0.93 [0.64–1.34] |
| Stricturing (B2) (n = 187) | 110 (24.1%) | 72 (33.8%) | 5 (26.3%) | 6.62×10−3 | 1.61 [1.14–2.27] |
| Penetrating (B3) (n = 329) | 231 (50.5%) | 92 (43.2%) | 6 (31.6%) | 9.06×10−2 | 0.76 [0.56–1.04] |
| Use of immuno-suppressive agents (n = 580) | no: 67 (17.2%) | 33 (18.8%) | 5 (33.3%) | 0.433 | 0.84 [0.54–1.30] |
| yes: 322 (82.8%) | 143 (81.3%) | 10 (66.7%) | |||
| Surgery because of CD (n = 807) | no: 260 (47.6%) | 111 (47.2%) | 16 (61.5%) | 0.782 | 0.96 [0.71–1.29] |
| yes: 286 (52.4%) | 124 (52.8%) | 10 (38.5%) | |||
| Fistulas (n = 821) | no: 281 (50.4%) | 128 (54.2%) | 18 (66.7%) | 0.168 | 0.81 [0.61–1.09] |
| yes: 277 (49.6%) | 108 (45.8%) | 9 (33.3%) | |||
| Stenosis (n = 823) | no: 239 (42.8%) | 82 (34.3%) | 16 (61.5%) | 0.111 | 1.28 |
| yes: 319 (57.2%) | 157 (65.7%) | 10 (38.5%) | [0.95–1.72] |
PG: p-value for association comparing carriers of the G-allele to individuals homozygous for A. Association results for age at diagnosis are based on median split. Uncorrected p-values<0.05 are depicted in bold. None of the p-values remained significant after Bonferroni correction for multiple testing (number of hypothesis tested: n = 15, resulting in a significance threshold of p<3.33×10−3).