Table 7. Genotype-phenotype associations of the PTPN2 SNP rs2542151 in UC patients.
| PTPN2 SNP rs2542151 | TT (n = 226) | TG (n = 80) | GG (n = 12) | PG | ORG [95% CI] |
| Gender (n = 318) | |||||
| Male | 125 (55.3%) | 36 (45.0%) | 5 (41.7%) | 8.03×10−2 | 1.54 [0.95–2.51] |
| Female | 101 (44.7%) | 44 (55.0%) | 7 (58.3%) | ||
| Age at diagnosis (yrs) (n = 302) | |||||
| Mean ± SD | 29.45±14.60 | 27.95±14.13 | 25.08±15.54 | 0.253 | 1.34 [0.81–2.21] |
| Range | 2–81 | 4–73 | 9–68 | ||
| Age at diagnosis (n = 302) | |||||
| < = 16 years (A1) (n = 59) | 41 (19.1%) | 16 (21.3%) | 2 (16.7%) | 0.926 | 0.97 [0.51–1.83] (A1 vs. A2) |
| 17–40 years (A2) (n = 183) | 126 (58.6%) | 49 (65.3%) | 8 (66.7%) | 9.95×10−2 | 1.81 [0.89–3.67] (A2 vs. A3) |
| >40 years (A3) (n = 60) | 48 (22.3%) | 10 (13.3%) | 2 (16.7%) | 0.189 | 1.76 [0.76–4.07] (A1 vs. A3) |
| BMI (kg/m2) (n = 209) | |||||
| Mean ± SD | 23.92±4.74 | 23.87±3.83 | 23.67±4.71 | 0.995 | 1.00 [0.55–1.82] |
| Range | 15–54 | 16–36 | 15–30 | ||
| Location (n = 200) | |||||
| Proctitis (E1) (n = 24) | 15 (12.0%) | 7 (10.6%) | 2 (22.2%) | 0.329 | 1.55 [0.64–3.70] |
| Left-sided UC (E2) (n = 96) | 73 (58.4%) | 20 (30.3%) | 3 (33.3%) | 0.184 | 0.68 [0.38–1.20] |
| Extensive UC (E3) (n = 80) | 37 (29.6%) | 39 (59.1%) | 4 (44.4%) | 0.473 | 1.22 [0.83–1.80] |
| Extra-intestinal manifestations (n = 191) | no: 87 (64.4%) | 33 (68.8%) | 5 (62.5%) | 0.652 | 0.86 [0.44–1.66] |
| yes:48 (35.6%) | 15 (31.3%) | 3 (37.5%) | |||
| Use of immuno-suppressive agents | no: 50 (26.0%) | 14 (20.9%) | 2 (22.2%) | 0.394 | 1.32 [0.70–2.50] |
| (n = 268) | yes: 142 (74.0%) | 53 (79.1%) | 7 (77.8%) | ||
| Abscesses (n = 240) | no: 160 (96.4%) | 61 (93.8%) | 7 (77.8%) | 0.151 | 2.35 [0.73–7.56] |
| yes: 6 (3.6%) | 4 (6.2%) | 2 (22.2%) |
PG: p-value for association comparing carriers of the G-allele to individuals homozygous for A. Association results for age at diagnosis and BMI are based on median split. None of the p-values remained significant after Bonferroni correction for multiple testing (number of hypothesis tested: n = 12, resulting in a significance threshold of p<4.167×10−3).