Table 8. Genotype-phenotype associations of the PTPN2 SNP rs7234029 in UC patients.
| PTPN2 SNP rs7234029 | AA (n = 220) | AG (n = 83) | GG (n = 11) | PG | ORG [95% CI] |
| Gender (n = 314) | |||||
| Male | 119 (54.1%) | 42 (50.6%) | 5 (45.5%) | 0.506 | 1.18 [0.73–1.91] |
| Female | 101 (45.9%) | 41 (49.4%) | 6 (54.5%) | ||
| Age at diagnosis (yrs) (n = 298) | |||||
| Mean ± SD | 29.95±14.90 | 26.32±13.49 | 30.50±12.70 | 0.401 | 1.24 [0.75–2.05] |
| Range | 3–81 | 2–73 | 14–57 | ||
| Age at diagnosis (n = 298) | |||||
| <16 years (A1) (n = 57) | 37 (17.5%) | 19 (25.0%) | 1 (10.0%) | 0.558 | 1.21 [0.64–2.26] (A1 vs. A2) |
| 17–40 years (A2) (n = 181) | 125 (59.0%) | 49 (64.5%) | 7 (70.0%) | 3.47×10−2 | 2.24 [1.06–4.73] (A2 vs. A3) |
| >40 years (A3) (n = 60) | 50 (23.6%) | 8 (10.5%) | 2 (20.0%) | 2.51×10−2 | 2.70 [1.13–6.45] (A1 vs. A3) |
| BMI (kg/m2) (n = 207) | |||||
| Mean ± SD | 23.97±4.66 | 24.10±4.26 | 22.90±3.18 | 0.975 | 0.99 [0.54–1.82] |
| Range | 15–54 | 15–36 | 20–29 | ||
| Location (n = 258) | |||||
| Proctitis (E1) (n = 24) | 13 (7.2%) | 11 (16.4%) | 0 (0%) | 7.75×10−2 | 2.15 [0.92–5.05] |
| Left-sided UC (E2) (n = 96) | 71 (39.2%) | 20 (29.9%) | 5 (50.0%) | 0.305 | 0.74 [0.42–1.31] |
| Extensive UC (E3) (n = 138) | 97 (53.6%) | 36 (53.7%) | 5 (50.0%) | 0.960 | 0.99 [0.58–1.68] |
| Extra-intestinal manifestations (n = 188) | no: 87 (66.4%) | 33 (63.5%) | 3 (60.0%) | 0.666 | 1.15 [0.60–2.21] |
| yes: 44 (33.6%) | 19 (36.5%) | 2 (40.0%) | |||
| Use of immunosuppressive agents (n = 266) | no: 50 (26.5%) | 15 (22.4%) | 1 (10.0%) | 0.332 | 1.37 [0.72–2.60] |
| yes: 139 (73.5%) | 52 (77.6%) | 9 (90.0%) | |||
| Abscesses (n = 238) | no: 161 (97.0%) | 58 (92.1%) | 7 (77.8%) | 3.94×10−2 | 3.47 [1.06–11.32] |
| yes: 5 (3.0%) | 5 (7.9%) | 2 (22.2%) |
PG: p-value for association comparing carriers of the G-allele to individuals homozygous for A. Association results for age at diagnosis and BMI are based on median split. Uncorrected p-values<0.05 are depicted in bold. None of the p-values remained significant after Bonferroni correction for multiple testing (number of hypothesis tested: n = 12, resulting in a significance threshold of p<4.167×10−3).