Table 9. Analysis for epistasis between PTPN2 SNPs and gene markers located in NOD2, IL23R and ATG16L1 in the CD-case control population.

Epistasis between	PTPN2 SNP rs2542151	PTPN2 SNP rs7234029
NOD2 SNPs
rs2066844 (p.Arg702Trp)	0.607	0.498
rs2066845 (p.Gly908Arg	0.219	0.916
rs2066847(p.Leu1007fsX1008)	0.208	0.276
IL23R SNPs
rs1004819	0.556	0.244
rs7517847	0.723	0.916
rs10489629	0.395	0.642
rs2201841	0.303	0.414
rs11465804	0.485	0.887
rs11209026 (p.Arg381Gln)	0.943	0.754
rs1343151	0.277	0.978
rs10889677	0.508	0.417
rs11209032	0.213	0.290
rs1495965	9.86×10−2	0.258
ATG16L1 SNPs
rs13412102	0.620	0.358
rs12471449	0.419	0.383
rs6431660	5.73×10−2	0.394
rs1441090	0.389	0.437
rs2289472	0.102	0.404
rs2241880 (p.Thr300Ala)	8.07×10−2	0.570
rs2241879	2.37×10−2	0.382
rs3792106	0.303	0.930
rs4663396	9.76×10−2	0.109

Uncorrected p-values<0.05 are depicted in bold. None of the p-values remained significant after Bonferroni correction for multiple testing (number of hypothesis tested: n = 44, resulting in a significance threshold of p<1.136×10⁻³).