Table 1. Characteristics of 20 patients with infections caused by a non–parapsilosis/guilliermondii Candida spp. Fks mutation, France, 2004–2010*.
| Patient no. | Age, y/sex | Underlying condition | Neutropenia | Species | Site of infection | Duration of caspofungin exposure, d† | Outcome at 30 d‡ |
|---|---|---|---|---|---|---|---|
| 1 | 34/M | HIV positive | No | C. albicans | Esophagus | 21 | Alive |
| 2 | 20/M | Hematologic malignancy: familial lymphohistiocytosis | Yes | C. albicans | Blood | 17 | Dead |
| 3 | 77/M | Hematologic malignancy: AML | Yes | C. albicans | Blood | 25 | Alive |
| 4 | 46/M | Hematologic malignancy: AML | Yes | C. albicans | Blood, peritoneum, pleural fluid | 26 | Dead |
| 5 | 34/F | Liver transplant: cirrhosis | No | C. albicans | Hepatic abscess, peritoneum | 60 | Alive |
| 6 | 64/F | Hematologic malignancy: AML; breast cancer | No | C. albicans | Blood | 25 | Alive at 17 d |
| 7 | 59/M | Teratocarcinoma | No | C. albicans | Pharynx | 35 | Dead |
| 8 | 28/M | Chronic mucocutaneous candidiasis | No | C. albicans | Pharynx, nails | 270 | Alive |
| 9 | 14/F | Hematologic malignancy: ALL | Yes | C. krusei | Lung | 45 | Alive |
| 10 | 79/M | Hematologic malignancy: non-Hodgkin lymphoma | Yes | C. krusei | Blood | 10 | Dead |
| 11 | 46/M | Hematologic malignancy: Burkitt lymphoma; HSCT | Yes | C. glabrata | Blood | None | Dead |
| 12 | 85/M | Gastric ulcer; CVC | No | C. glabrata | Blood | 32 | Alive |
| 13 | 28/M | Hematologic malignancy: non-Hodgkin lymphoma; HSCT | No | C. glabrata | Palate§ | 135 | Alive |
| 14 | 48/M | Esophageal cancer | No | C. glabrata | Blood | 12 | Alive |
| 15 | 41/M | Liver transplant: fulminant hepatitis | No | C. glabrata | Blood, peritoneum | 37 | Dead |
| 16 | 38/F | Hematologic malignancy; AML; HSCT | Yes | C. glabrata | Blood | 51 | Dead |
| 17 | 60/M | Acute pancreatitis; GI tract surgery | No | C. glabrata | Bile | 34 | Alive |
| 18 | 39/M | Hematologic malignancy: AML; HSCT | No | C. glabrata | Sinus§ | 15 | Alive |
| 19 | 55/F | Lock-in syndrome; neurogenic bladder | No | C. glabrata | Urine¶ | 27 | Alive |
| 20 | 63/M | Colon cancer | Yes | C. glabrata | Blood | 14 | Alive |
*AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; HSCT, hematopoietic stem cell transplantation; CVC, central venous catheter; GI, gastrointestinal. †Duration of caspofungin exposure before isolation of the first resistant Candida isolate. ‡Outcome 30 d after isolation of the first resistant Candida isolate. §From a biopsy specimen. ¶With sepsis.