Figure 1. SUMO family proteins.
The alignment shows the sequences of human ubiquitin, SUMO-1, SUMO-2, SUMO-3, SUMO-4, Smt3 (Smt3p) and Pmt3 (Pmt3p). Residues identical in all proteins are shown on a cyan background, and include the C-terminal di-glycine motif required for conjugation to substrate proteins (bold). Residues showing only conservative changes across all four proteins are shown in on a pink background and residues showing semi-conservative changes among each of the proteins are shown on a yellow background. Sequence alignment and determination of conservation was performed using the ClustalW program.