Table 1.

Basic parameters in db/db mice and their controls.

Basic parameters	m+/db (n = 10)	Valsartan (n = 10)	LAF237 (n = 10)	Combo (n = 10)	db/db (n = 10)
Body mass (g)
4w	17.5 ± 1.9	26.3 ± 2.1	25.6 ± 2.8	24.1 ± 2.2	25.8 ± 3.4
12w	27.5 ± 2.9∗#	41.2 ± 4.0#	35.3 ± 3.7*	36.4 ± 3.9*	40.8 ± 4.3
Glucose (mmol/L)
4w	6.3 ± 1.2∗#	8.7 ± 1.1	8.2 ± 1.4	8.5 ± 0.8	8.1 ± 1.2
12w	8.2 ± 1.4∗#	22.4 ± 2.7#	17.5 ± 2.4*	17.8 ± 2.2*	25.3 ± 3.3
Triglycerides (mmol/L)
4w	0.65 ± 0.07∗#	1.23 ± 0.14	1.21 ± 0.18	1.24 ± 0.16	1.22 ± 0.23
12w	0.70 ± 0.05∗#	1.73 ± 0.20	1.65 ± 0.18*	1.62 ± 0.14*	1.85 ± 0.29
Cholesterol (mmol/L)
4w	2.37 ± 0.26∗#	3.70 ± 0.32	3.73 ± 0.45	3.68 ± 0.34	3.71 ± 0.41
12w	2.42 ± 0.18∗#	3.46 ± 0.32#	3.23 ± 0.24*	3.15 ± 0.28*	3.52 ± 0.38
LDL (mmol/L)
4w	0.96 ± 0.03∗#	1.53 ± 0.12	1.55 ± 0.17	1.56 ± 0.15	1.54 ± 0.22
12w	0.92 ± 0.04∗#	1.38 ± 0.11*	1.42 ± 0.16*	1.37 ± 0.16*	1.63 ± 0.21
HDL (mmol/L)
4w	1.17 ± 0.15∗#	1.55 ± 0.14	1.53 ± 0.16	1.56 ± 0.18	1.58 ± 0.17
12w	1.20 ± 0.16∗#	1.69 ± 0.18∗#	1.83 ± 0.25	1.98 ± 0.27*	1.73 ± 0.14

Values are presented as mean ± SD.

*P < 0.05 versus db/db group, ^# P < 0.05 versus combined treatment group.