Table 1.
Baseline values for demographic, cognitive, and functional variables.
| N | Mean | SD | Minimum | Maximum | |
|---|---|---|---|---|---|
| Demographic and clinical variables | |||||
| Age | 357 | 77.6 | 7.4 | 51 | 103 |
| Education (years) | 357 | 12.3 | 3.4 | 2 | 21 |
| Male | 163 (46%) | ||||
| Cholinesterase inhibitor drug use | 249 (64%) | ||||
| BPRS total score | 355 | 27.5 | 12.1 | 4 | 66 |
| Neuropsychiatric Rating Scale | 354 | 36.6 | 18.2 | 3 | 104 |
| ADCS-ADL scale score | 353 | 39.7 | 16.7 | 6 | 76 |
| Cognitive variables | |||||
| MMSE Score | 355 | 15.2 | 5.7 | 4 | 28 |
| BPRS cognitive factor | 355 | 5.3 | 2.4 | 0 | 12 |
| ADAS-Cog | 328 | 34.4 | 13.3 | 8 | 67 |
| ADAS concention/distraction | 333 | 1.8 | 1.5 | 0 | 5 |
| ADAS number cancellation | 306 | 10.5 | 7.9 | 0 | 38 |
| ADAS executive function (maze) | 291 | 68.1 | 84.2 | 3 | 240 |
| Category Instances | 317 | 6.4 | 4.2 | 0 | 21 |
| Finger Tapping preferred hand | 290 | 28.9 | 14.5 | 0 | 75 |
| Finger Tapping non-preferred hand | 289 | 26.8 | 13.4 | 0 | 75 |
| Trails A (time, seconds) | 245 | 111.5 | 97.1 | 20 | 300 |
| Working memory deficita | 72 | 1.0 | 0.9 | 0 | 3.0 |
| Cognitive summaryb | 301 | 0 | 1.0 | −2.7 | 1.8 |
a
The working memory deficit is the difference between the 10-second-delay score and the no-delay score (deficit scores were considered to be missing in patients with no-delay scores above 4.0).
b
The cognitive summary was the normalized average of the sign-adjusted, normalized, baseline z-scores for each of the 11 components of the ADAS-Cog, ADAS Concentration/Distractibility, ADAS Number Cancellation, ADAS Executive Function, Category Instances, the mean of the scores for the preferred and the non-preferred hand on the Finger Tapping Test, Trails A, and the working memory deficit.